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Six Effects of Enzymes in the Human Body

Six Effects of Enzymes in the Human Body

Do you know when enzymes begin to be produced in the human body? The answer is that they existed during the egg and sperm period. It is also because of the activity of the enzyme that the egg and sperm can be combined. Cell division must use enzyme because the medium,...

5G in new directions just got Weird

5G in new directions just got Weird

Industry group 3GPP takes 5G in new directions in the latest set of standards The only reason you’re able to read this right now is because of the Internet standards created by the Internet Engineering Task Force. So while standards may not always be the most exciting...

Researchers Turning Bricks Into Supercapacitors in 2020

Researchers Turning Bricks Into Supercapacitors in 2020

Researchers at Washington University in St. Louis made a fast energy storage device out of common building bricks As solar panels and wind turbines multiply, the big problem is how with how to store all the excess electricity produced when the sun is up or the wind...

Human Sperm Don’t Swim Like We Thought

Human Sperm Don’t Swim Like We Thought

3D microscope reveals that sperm have been fooling scientists for 350 years For more than three centuries scientists have believed that human sperm swim by swishing their tails in a side-to-side, symmetrical motion. But that’s because we’ve been...

Path to Powerful Analog AI found by Startup and Academics

Path to Powerful Analog AI found by Startup and Academics

Equilibrium propagation allows all-analog training Engineers have been chasing a form of AI that could drastically lower the energy required to do typical AI things like recognize words and images. This analog form of machine learning does one of the key mathematical...

Why Sweat Will Power Your Next Wearable

Why Sweat Will Power Your Next Wearable

Biofuel cells can generate enough watts for fitness trackers and health monitors- By Patrick Mercier and Joseph Wang Here’s how a wearable turns sweat into energy: A fuel cell consists of two electrodes—an anode and a cathode—with an electrolyte between them. The fuel...

Spherical Silicon Solar Cells Absorb Scattered Sunlight

Spherical Silicon Solar Cells Absorb Scattered Sunlight

Silicon solar cells folded into spheres hint at solar power's flexibility in even small devices By Jeremy Hsu The spherical solar cell also delivered about 60 percent more power output than its flat counterpart when both could collect only scattered sunlight under a...










Handheld Vagus Nerve Stimulator Gets Emergency Approval for COVID-19 Use

by | Jul 23, 2020 | Tech News | 0 comments




Electric pulses open airways and could combat deadly “cytokine storm”

By Samuel K. Moore

The U.S. Food and Drug Administration has granted an emergency use authorization for treating suspected COVID-19 patients with a non-invasive vagus stimulator. The handheld device, made by electroCore, in Basking Ridge, N.J., sends a train of electrical pulses through the skin to a nerve within the neck. Research has shown this pulse train causes airways within the lungs to open and should even have a more general anti-inflammatory effect.

According to FDA’s authorization, the gammaCore Sapphire CV device are often used either reception or during a clinic or hospital to “acutely treat adult patients with known or suspected COVID-19 who are experiencing exacerbation of asthma-related [shortness of breath] and reduced airflow, and for whom approved drug therapies aren’t tolerated or provide insufficient symptom relief.”

The vagus nerves line either side of the neck and connect structures deep within the brain with the body’s internal organs. (See “The Vagus Nerve: A Back Door For Brain Hacking,” June 2015.) Medical device makers have been taking advantage of this brain-organ highway to treat epilepsy, depression, postpartum bleeding, and more. ElectroCore’s device is already approved for both acute and long-term treatment of migraine and cluster headaches.

However, the corporate was founded on the rear of research into the vagus stimulations’ effect on airways, says Dr. Peter Staats, electroCore’s chief medical officer. “Early on, once we were studying airway activity, we asked patients if they experienced anything ,” he recalls. “An early patient said ‘My headache went away.’” Once the company was established, headache became the initial focus. Conveniently, an equivalent set of stimuli used for migraine and headache—two minutes of 25 pulses per second of a 5000 Hz signal—also work for the lungs. “We’ve kind of come full circle,” says Staats.

With reference to the lungs and COVID-19, the device appears to possess a two-pronged effect. The first, opening up the top terminals of the lung’s airways, is mediated by signals rising the nerve into the brain, says Staat. The second, a separate anti-inflammatory effect, appears to be caused by signals traveling down the nerve into the body. The working theory is that this second signal has an impact on cytokine production. Cytokines are a broad class of small proteins that cells use to signal to every other, a number of which play a task in inflammation. Their overproduction can cause a “cytokine storm syndrome” that’s been seen in some COVID-19 patients, where an immune reaction spins out of control and may pack up the lungs and other organs.

Under the FDA authorization, the device is merely approved to be used during the COVID-19 national emergency. However, researchers have several ongoing clinical trials and FDA has invited the corporate to hunt more permanent approval, consistent with electroCore CEO Dan Goldberg. And he expects the corporate to continue exploring the utilization of noninvasive vagus stimulation (nVNS) for other maladies, he says. “Under the pandemic circumstances we’re laser focused, but we still believe that nVNS may be a broad platform for a spread of clinical indications,” he says.










200 CIVIL ENGINEERING Interview Questions & Answers

200 CIVIL ENGINEERING Interview Questions & Answers

200 CIVIL ENGINEERING Interview Questions & Answers 1. What are the causes of building collapse?The passage of time is one reason. Buildings also collapse due to weak foundations. Earthquakes, hurricanes and other natural disasters can also damage the structure of...

Tesla Valve Working

Tesla Valve Working

Nikola Tesla had invented a very interesting one-way value. Let's understand the complete physics of this valve in this video. https://youtu.be/suIAo0EYwOE

Jobs in TATA

Jobs in TATA

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